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Mice that are exposed to a PUFA-enriched Western diet and that lack one Gpx4 allele in IECs (Gpx4 +/IEC ), but not wild-type (WT) mice, display signs of epithelial LPO and focal neutrophilic enteritis with granuloma-like accumulation of inflammatory cells

10.4103/jpn.JPN_130_19 4 BaoZ

While most of this research has been done in controlled environments, it gives us valuable insight into why GHK-Cu may also benefit aging skin because aging and healing are closely connected

Most peptides are degraded in the GI tract before they can exert biological effects, but KPVs small size (three amino acids) and PepT1 affinity allow it to reach intestinal tissue intact